MilkyWay@home Fundraiser- November 2014
Source:  Milkyway@home
jeudi 6 novembre 2014 18:29

Hi everyone,

Here is a letter from Professor Heidi Newberg:

"Dear Milkyway@home volunteer,

Last July I sent out a plea to MilkyWay@home volunteers to help save our project when our National Science Foundation grant was not renewed. I am happy to report that we have so far raised $37,991 towards a goal of $40,480. We are so close!! Many thanks to the wonderful MilkyWay@home volunteers, my family, and the parents of my former graduate students for keeping us afloat thus far. Donations have come in by credit card, check, PayPal, transfers from donor advised funds, and we received over $3000 from BitCoinUtopia (http://www.bitcoinutopia.net/bitcoinutopia/), which is collecting cryptocurrencies to support our research.

If you are able and willing to help but have not yet made a donation, then now is your chance. To raise the additional $2489 needed, we need thirty-six people to donate $15, twenty people to donate $40, nine people to donate $100, and one very generous person to donate $250. I hope that by next week, we will be able to announce on Facebook (https://www.facebook.com/Milkywayathome) that we have met or exceeded the goal! Gifts made directly to MilkyWay@home are tax deductible in the US and Canada. Volunteers will receive an on-line badge for donations of any size. For every $100 donated before December 1, 2014, we will send you a free T-shirt (S, M, L, XL, XXL, or XXXL), designed by our team members, that says “I support MilkyWay@home.” After December 1, we will send T-shirts if they are available in your size, but they will not be reprinted.

Already, donated funds have supported undergraduate student Jake Weiss, who is doing a semester of employment on MilkyWay@home. It also payed for travel for our collaborator Larry Widrow to travel to Rensselaer and help us implement new algorithms. Five poster presentations on MilkyWay@home research (three students, one former student, and myself) have been accepted for the January 2015 meeting of the American Astronomical Society; travel to that meeting will be paid by your donations. So far, we are right on track with our budgeting.

Some have asked me if this is a one-time request for funding, or whether this will become the primary source of funding for MilkyWay@home. I recently saw a presentation on funding trends given by the head of the US National Science Foundation Astronomy Division, and I can tell you that the funding projections for federal grants that fund projects like MilkyWay@home are not good. I am expecting that while we need federal funding to keep our project vibrant in the long term, we cannot count on it as the only source into the future. I am working on ways to broaden our support base beyond MilkyWay@home volunteers, to include foundation and corporate support as well as tapping into new funding models for reaching philanthropists with an interest in supporting science.

If you are a person who makes year-end donations, I would really appreciate your adding MilkyWay@home to the list of organizations that you support. We have great plans to discover where dark matter is in the Milky Way over the next ten years. That goal requires significant advances in our computer algorithms that run n-body simulations and that requires the efforts of many students to achieve. Any funds received in excess of our goal this year will be used on additional student salaries. Since most of the funds will be expended on student salaries in summer 2015, we will post a report of the funding used and results achieved in September, 2015.

I and the MilkyWay@home team thank you so much for keeping our research alive!

In appreciation,
Prof. Heidi Jo Newberg and the MilkyWay@home team
"


WU: UBI
Source:  GPUGrid
mercredi 5 novembre 2014 14:50

Hey all, I am starting some new simulations whose names begin with ubi. They are relatively few so you might not notice them much around. Essentially, after some success in folding the NTL9 protein (see previous WU posts) with a new method I was testing, I wanted to scale it up to a bigger, slower-folding (and more famous) protein and see how my method works on it. So here we go with Ubiquitin. If this one is also kind enough to fold fast for me, we might be onto something quite useful :)


OGR: 1,000,000,000 GNodes
Source:  yoyo@home
dimanche 2 novembre 2014 00:00

The Boinc team tested now 1,003,453,991 GNodes of the distributed.net OGR project. This is 11.9% of the whole project.


New publication: Our study of a disordered protein and its significance
Source:  GPUGrid
mercredi 29 octobre 2014 14:04

Hi everyone, We are very pleased to announce the publication of our latest research article, titled "Kinetic modulation of a disordered protein domain by phosphorylation", which was published yesterday in the journal Nature Communications. You can see the official journal page link here. Since we know most of you don't have access to the fancy formatted version from Nature Publishing Group, we have placed the our less-fancy formatted pre-print version of the article here (first PDF link at the top of the page). Since I am sure the title and abstract is quite cryptic/confusing to everyone, let me explain what we discovered and why this work was important. The main focus of the paper was a disordered protein domain called KID. Disordered proteins like KID do not have any rigid structures (so no x-ray crystal structures), and are in fact very flexible like polymers. However, despite being flexible they are very important and common in many different aspects of cell biology. They are important in many protein-protein interactions, such as ones that are important in communication inside the cell. They are frequently involved in many diseases like cancer (among many others). KID is a protein that has been studied for more than 15 years, and a lot was already known about it. Other proteins in the cell chemically modify KID through a process known as phosphorylation, which then causes it to bind to specific proteins. It binds most famously to a protein known as KIX. The behavior of KID in the phosphorylated and normal state has been studied by a technique known as NMR (a cousin of MRI), and the binding of KID to KIX has also been studied this way. However, what we discovered in our study—and not seen by any other method yet—was that when KID is phosphorylated, it undergoes an a slowdown in its motions and forms a temporary, partially folded state. We believe this state is important in the binding process, and modelling and comparison with previous experiments also suggest this. This work is significant because it is the first time anyone has shown that such chemical modifications could change the behavior of a protein in this way, and also that it could have important consequences for the way proteins interact. If you have questions, please ask away. We will assign badges and update the webpage soon.


Bitcoin Donations
Source:  yoyo@home
jeudi 23 octobre 2014 00:00

You can send donations now also via Bitcoin to our Bitcoin address. Infos on our donation page.


Competition 'SAT@home. Three years with the project.'
Source:  SAT@home
jeudi 23 octobre 2014 08:06

Competition SAT@home. Three years with the project. will be held from October 3 2014 to October 10 2014.

Соревнование SAT@home. Три года с проектом. будет проведено с 3 по 10 октября 2014 года.


12-digit factor of P2203 has now been found by the project...
Source:  WEP-M+2 Project
dimanche 19 octobre 2014 12:53

...56186 times


Planned outage
Source:  NFS@Home
vendredi 17 octobre 2014 01:13

The NFS@Home project will be offline for part of this weekend due to a planned data center outage. Everything should be back online Sunday.


GPUGRID statistics graphs
Source:  GPUGrid
jeudi 16 octobre 2014 03:17

Following up on the announcement to discontinue support for old hardware and the oldest application, here are two graphs showing the normalised throughput of GPUGRID broken down by compute capability and application version. http://www.gpugrid.net/graphs/ The legends are messed up for some reason - the first graph is cc, {1.3, 2.0, 2.1, 3.0, 3.5, 5.0, 5.2 }, the second app version {42, 60, 65} These will update daily. Matt


GARLI 2.1 released
Source:  The Lattice Project
mercredi 15 octobre 2014 19:48

I have just released GARLI 2.1 for five platforms (32 and 64 bit Linux, 32 and 64 bit Windows, 64 bit OS X), and have deprecated the 32 bit OS X app version. This version should improve data set load times for large analyses, and may include other improvements that you would notice. Please post if you encounter any problems running the new version.



   

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