samedi 24 septembre 2016 06:54
Looks like the database has been down for a little over 30 hours and the boinc daemons are still struggling. Not entirely sure what happened, but I'm working through trying to fix it. I apologize for the slow progress being made, all of the major MilkyWay@home scientists, including myself are visiting collaborators in Canada and have been quite busy. I will try to get things fixed over night.
Everything seems to be working now. I'll check back in the morning to make sure everything is still working.
|Project News Sep 23, 2016|
vendredi 23 septembre 2016 09:00
Some good news! We recently published an article in Nature titled "Accurate de novo design of hyperstable constrained peptides". We would like to thank all Rosetta@Home participants for their help with this work. In the paper, we present computational methods for designing small stapled peptides with exceptional stabilities. These methods and designed peptides provide a platform for rational design of new peptide-based therapeutics. Constrained (stapled) peptides combine the stability of conventional small-molecule drugs with the selectivity and potency of antibody therapeutics. The ability to precisely design these peptides in custom shapes and sizes opens up possibilities for "on-demand" design of peptide-based therapeutics. Other developments described in the paper: We can now accurately design 18-47 amino acid peptides that incorporate multiple cross-links. We can now design peptides that incorporate unnatural amino acids. Specifically, we designed peptides with a mix of natural L-amino amino acids and D-amino acids (mirror images of L-amino acids). D-amino acids tend to provide better protease resistance and lower immunogenicity; both of which are desired properties in a therapeutic peptide. Unnatural amino acids also let us sample much more diverse shapes and functions. We can now design peptides that are cyclized via a peptide bond between their N- and C-terminus. Cyclic peptides provide increased resistance against exopeptidases as they have no free ends, and thus are ideal candidates for engineering peptide therapeutics. We are now working to use these computational methods for designing peptides that target therapeutically relevant targets, such as, enzymes that impart antibiotic resistance in pathogenic bacteria. Structure prediction runs on Rosetta@Home for these designed peptide models played a key role in selection of good designs that were experimentally synthesized and characterized. Thank you all for your help in making this work possible! -- Gaurav B. For more information: IPD News. Nature paper "Accurate de novo design of hyperstable constrained peptides". Nature review "The coming of age of de novo protein design".
|Some security and cosmetic upgades|
Source: Cosmology@Home: News
jeudi 22 septembre 2016 17:19
We have added the option to access the C@H website more securely via "https", if you'd like to do so, you can update your bookmarks to use https://www.cosmologyathome.org. For now this remains purely optional (for example, if you don't know what https is, you can ignore this). At some point in the future, we will likely move to requiring this, but we'll give warning and post more details then.
Also, I've fixed a number of minor cosmic things about the site, most notably 1) the BBCode buttons when posting to the forums now work 2) a number of pages which were rendered too wide should now correctly fit the screen. If, as you're using the site, you find any other glitches, please don't hesitate to take a screenshot and post on the forums so we can fix things! Thanks all! (Edit: ha, oops meant to say *cosmetic* things above, although I'll leave in the somewhat appropriate typo)
|SSL connection option|
jeudi 22 septembre 2016 11:30
For those with BOINC clients above version 7.2, there is now an option to connect with SSL on the URL:
This server runs a web-front end and scheduler for this project. To use it, please detach fron the project, and re-attach using the new HTTPS URL.
The other project daemons still run on the same server as before. The old server and URL will remain in place until further notice.
So far our tests of this distributed server setup works fine, and we would appreciate feedback in case of problems.
|A Family's Experience with Neuroblastoma|
Source: World Community Grid News and Updates
mardi 20 septembre 2016 20:54
September is Childhood Cancer Awareness Month. This month is special to us because of our successful Help Fight Childhood Cancer project, which helped researchers find several promising treatments for neuroblastoma, a deadly childhood cancer. In this article, a volunteer describes her family's experience after her young daughter was diagnosed with neuroblastoma.
|MilkyWay@home Version 1.38 Released|
lundi 19 septembre 2016 21:36
I just released the newest version of the MilkyWay@home application (1.38). The only major change to this version is an inclusion of the newest BOINC libraries in an attempt to improve compatibility with the new graphics cards.
Mac users will still receive the 1.36 application version for the time being while we work on securing a new Mac computer to build and test on for the future.
If you notice any issues with this application please post them here.
|12-digit factor of P2203 has now been found by the project...|
Source: WEP-M+2 Project
lundi 19 septembre 2016 12:53
|Migration to SSL|
vendredi 16 septembre 2016 16:18
The scheduler and web pages of this dev project are now also published on the URL:
Please detach and re-attach to this new URL with your BOINC clients. The old project server is still running, and also the file upload and validation daemons run on the old server for now.
Later on after a test period, we will redirect the old URL. Then we will proceed in a similar way with our production project.
|No new tasks temporarily|
vendredi 16 septembre 2016 10:27
Work generetor was temporarily stopped. We are going to move the project to a new sever approximately in November, so we need all tasks to be processed.
Генератор заданий временно остановлен. Мы собираемся перенести проект на новый сервер в ноябре, поэтому нам нужно, чтобы все задания были обработаны.
|2,1954M, 2,1982M, 2,1009+, 2,1019+, XYYXF 139,122, and XYYXF 147,136 factored|
jeudi 15 septembre 2016 20:51
We have completed 2,1954M, 2,1982M, 2,1009+, and 2,1019+ from the Cunningham Project, and 139,122 and 147,136 from the XYYXF project. Details of all of these factorizations are available on the Status of Numbers page. Let's keep it up!
[Edited to add 2,1019+]