Actualités en direct des projets (non traduites)

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Welcome to 2023! And just days away, on Jan. 22, in the Lunar Chinese calendar: the year 4721. What do you know, a prime number! The first challenge of the 2023 PrimeGrid Challenge Series will be a 3-day challenge on the PPS-MEGA and GFN-17 MEGA applications, beginning 22 January 12:00 UTC and ending 25 January 12:00 UTC. To participate in the Challenge, please select only the Proth Mega Prime Search (LLR) and Generalized Fermat Prime Search n=17 projects in your PrimeGrid preferences section. Inquiries? Ideas? Impressions? Interjections? Inferences? Join the discussion at https://www.primegrid.com/forum_thread.php?id=10115&nowrap=true#159335

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Création : 21 janvier 2023

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...395219 times

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Création : 17 janvier 2023

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Dear participants,

After doing initial studies on an established SARS-CoV-2 target RNA dependent RNA polymerase (RdRp), we are departing from protease studies and focus on RdRp along with additional NSP targets. Namely, RdRp (NSP12), is responsible for the transcription of viral genes and ultimately replication of the viral genome. The studied active site binds RNA and was previously studied in the context of remdesivir, galidesivir, molnupiravir and several other small molecules. Further reading below:

• Structure of replicating SARS-CoV-2 polymerase
  
• Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity
  
• RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2
  
• Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
  

Figure 1: RdRp in white color along with RNA chain and N4-hydroxycytidine from Molnupiravir in the active site (red stick model).

With best wishes,
Natalia, Marko, ÄŒrtomir, hoarfrost.

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Création : 15 janvier 2023

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Dear participants!

We created new applications named as "CurieMarieDock 0.2.0 long tasks" and "CurieMarieDock 0.2.0 short tasks", both based on CmDock 0.2.0 release. Algorithm of both applications are identical, but for "short tasks" we created only ARM-version and we plan to generate a special, smaller in 5 times tasks that covers one of part of entire tasks set. We advice all owners of small single-board computers like Raspberry Pi, to switch to "short tasks" application.

In next 1 .. 2 days we continue to generate new tasks "Sprot_delta_v1" (extended run) for both application, but later we issue a sample tasks set for new target (# 22) and only for "long application" because all task of sample set will be large. Simultaneously, project will continue to send Sprot_delta_v1 tasks for "short" application. And then we will proceed to sent long and short tasks for appropriate applications.

Hope that this explanation makes situation is clear.

Thank you for participation and donation of CPU time!

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Création : 13 janvier 2023

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As I said. We are currently compiling the Windows version. GDF

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Création : 10 janvier 2023

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Simone Bonzanini found a 67 digits prime factor for the Cuningham number 22222+1. This saves a lot of NFS effort. The found prime is the first for this years ECMNET record list of Paul Zimmermann.

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Création : 8 janvier 2023