Happy holiday season
Source:  GPUGrid
mardi 16 décembre 2014 16:23

Hopefully, a lot more GPUs and CPUs will join after the holiday presents. At GPUGRID we are going away starting next week. The first to come back is Nate by the end of the year, early new year. Also still remember that if you want, there is the possibility to make a donation. Donations are used to fund a PhD student which can work on Gpugrid. Last year we have received many donations. Thanks to everybody. This year we also did well in terms of scientific publications: N. Stanley, S. Esteban and G. De Fabritiis, Kinetic modulation of a disordered protein domain by phosphorylation, Nat. Commun. 5, 5272 (2014). pdf G. Lauro, N. Ferruz, S. Fulle, M. J. Harvey, P. W. Finn, and G. De Fabritiis,Reranking Docking Poses Using Molecular Simulations and Approximate Free Energy Methods, J. Chem. Inf. Model., 2014, 54 (8), pp 2185–2189. *** S. Doerr and G. De Fabritiis, On-the-fly learning and sampling of ligand binding by high-throughput molecular simulations, J. Chem. Theory Comput. 10 (5), pp 2064–2069(2014).pdf P. Bisignano, S. Doerr, M. J. Harvey, A. Favia, A. Cavalli and G. De Fabritiis, Kinetic characterization of fragment binding in AmpC β-lactamase by high-throughput molecular simulations, J. Chem. Inf. Model., 2014, 54 (2), pp 362–366. pdf X. Huang and G. De Fabritiis, Understanding Molecular Recognition by Kinetic Network Models Constructed from Molecular Dynamics Simulations, Adv Exp Med Biol 2014; 797: 107-114. pdf ** E. Dainese, G. De Fabritiis, A. Sabatucci, S. Oddi, C. Angelucci, C. Di Pancrazio, T. Giorgino, N. Stanley, B. Cravatt, and M. Maccarrone, Membrane lipids are key-modulators of the endocannabinoid-hydrolase FAAH, Biochem J. 2014 Feb 1;457(3):463-72. Almost all of these works have been made with your contribution. From next year we are also trying to have a larger impact in biomedicine, further developing new small molecules which can be used for treatment of disease. Best, gdf


PPS MEGA Prime Found!
Source:  PrimeGrid
samedi 13 décembre 2014 17:09

On 1 December 2014, 8:02:57 UTC, PrimeGrid’s Mega Prime Search found the Mega Prime: 255*2^3395661+1 The prime is 1,022,199 digits long and enters Chris Caldwell's The Largest Known Primes Database ranked 107th overall. The discovery was made by John Christy (John Christy) of the United States using an Intel(R) Xeon(R) CPU E31220 @ 3.10GHz with 8GB RAM running Linux. This computer took about 1 hour 27 minutes to complete the primality test using LLR. John is a member of the USA team. The prime was verified on 3 December 2014, 21:47:43 UTC, by Scott Bedenbaugh (PixelSmasher8) of the United States using an AMD FX(tm)-8320 Eight-Core Processor with 16 GB RAM running Microsoft Windows 7 Professional. This computer took about 4 hours and 54 minutes to complete the primality test using LLR. Scott is a member of the SEACOAST -- SouthEAst COalition of Alien Signal Trackers team. For more details, please see the official announcement.


Fixed credit system was launched
Source:  SAT@home
vendredi 12 décembre 2014 14:14

Fixed credit system was launched. In the current experiment 130 credits are granted for each WU.

Запущена система с фиксированными кредитами. В текущем эксперименте за каждый WU выдается 130 кредитов.


321 Mega Prime!
Source:  PrimeGrid
mardi 9 décembre 2014 22:03

On 22 November 2014, 14:46:02 UTC, PrimeGrid’s 321 Prime Search project found the mega prime: 3*2^11484018-1 The prime is 3,457,035 digits long and enters Chris Caldwell's The Largest Known Primes Database ranked 12th overall. This is the largest known 321 mega prime and the largest prime found to date at PrimeGrid! The discovery was made by Serhiy Gushchak (Sergyg) of the Ukraine using an Intel(R) Core(TM) i3-2120 CPU @ 3.30GHz with 12 GB RAM running Microsoft Windows 7 Ultimate. This computer took about 27 hours and 2 minutes to complete the primality test using LLR. Serhiy is a member of the Ukraine Team. The prime was verified on 24 November 2014 11:24:03 UTC, by Thomas Schulze Curly of Germany using an Intel(R) Core(TM) i7-3770K CPU @ 3.50GHz with 16 GB RAM running Microsoft Windows 7 Professional. This computer took about 32 hours and 56 minutes to complete the primality test using LLR. Thomas is a member of the BOINCStats Team. For more details, please see the official announcement.


New Modfit Runs
Source:  Milkyway@home
mardi 9 décembre 2014 22:36

Hey Everyone,

Just a heads up, I will be starting new runs over the next couple days that will have a different step size in a computationally intensive section of our code. Through some work we did, we found that this step size could be optimized and reduced to improve the speed at which our code runs without sacrificing accuracy. We expect to see these runs complete in about 1/5th the time depending on the platform. Credits will hopefully still be calculated correctly, but if you think they are not for these runs please post here. If these runs cause you any trouble with these runs or you notice you stop receiving work units please post that here too. These runs will all include the tag _fast_ in the work unit name so it should be easy to track.

For now, these optimizations will only be used on the Modfit code, but in the near future we plan on also using them on original separation code, too.

If you have any questions about this optimization or problems, please let me know,

Jake


Winter Solstice Challenge starts Dec 18th 23:03 UTC
Source:  PrimeGrid
lundi 8 décembre 2014 23:10

Dear all, The end of the year is drawing closer and this is traditionally marked with the winter solstice challenge here at PrimeGrid. As in previous years we would like to invite everyone to join us in this celebration of tidings of comfort and joy by sieving away for the Proth Prime Search. The challenge will start on Dec 18 23:03 UTC and last for 72 hours. For more information, cheery banter and general merrymaking please join us on the discussion board. We hope to see you there and please do spread the word :)


Final workunits for SIMAP: about 5 days remaining
Source:  SIMAP - Similarity Matrix of Proteins
lundi 8 décembre 2014 08:29

The last workunits for SIMAP are currently distributed. We assume about 5 days of work distribution left. Beyond these, there will be no more work in this project. Thanks to all of you for crunching protein similarities. Best wishes Thomas


Help researchers find an Ebola cure
Source:  World Community Grid News and Updates
mercredi 3 décembre 2014 03:35

The Ebola virus is a significant global health threat and is responsible for a growing humanitarian crisis in West Africa. Currently, there are no proven treatments or vaccines. We’re launching Outsmart Ebola Together to help researchers find a cure. Dr. Erica Ollmann Saphire of The Scripps Research Institute tells us more about the project and what she hopes to achieve together.


Finding new solutions for a neglected tropical disease
Source:  World Community Grid News and Updates
vendredi 28 novembre 2014 13:39

Team leader Dr. Carlos Muskus provided this extensive update on the progress of the Drug Search for Leishmaniasis project.


FightNeglectedDiseases@Home server is up... and almost running
Source:  FightMalaria@Home
mercredi 26 novembre 2014 19:40

Dear all,

The long awaited revamp of the FM@H server has finally happened - thanks to Benjamin. And thanks to the generous donations that we collected at the http://www.gofundme.com/1l0u2o website we were able to buy another SSD to build the FiND@H server on. This should be super-fast and will allow us to venture into different diseases beyond malaria, using the same 'whole genome docking' approach.

We should have the first work-units ready within a week or two.

Thanks again for your patience.

ciao,
Ant



   

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