New publication: Our study of a disordered protein and its significance
Source:  GPUGrid
mercredi 29 octobre 2014 14:04

Hi everyone, We are very pleased to announce the publication of our latest research article, titled "Kinetic modulation of a disordered protein domain by phosphorylation", which was published yesterday in the journal Nature Communications. You can see the official journal page link here. Since we know most of you don't have access to the fancy formatted version from Nature Publishing Group, we have placed the our less-fancy formatted pre-print version of the article here (first PDF link at the top of the page). Since I am sure the title and abstract is quite cryptic/confusing to everyone, let me explain what we discovered and why this work was important. The main focus of the paper was a disordered protein domain called KID. Disordered proteins like KID do not have any rigid structures (so no x-ray crystal structures), and are in fact very flexible like polymers. However, despite being flexible they are very important and common in many different aspects of cell biology. They are important in many protein-protein interactions, such as ones that are important in communication inside the cell. They are frequently involved in many diseases like cancer (among many others). KID is a protein that has been studied for more than 15 years, and a lot was already known about it. Other proteins in the cell chemically modify KID through a process known as phosphorylation, which then causes it to bind to specific proteins. It binds most famously to a protein known as KIX. The behavior of KID in the phosphorylated and normal state has been studied by a technique known as NMR (a cousin of MRI), and the binding of KID to KIX has also been studied this way. However, what we discovered in our study—and not seen by any other method yet—was that when KID is phosphorylated, it undergoes an a slowdown in its motions and forms a temporary, partially folded state. We believe this state is important in the binding process, and modelling and comparison with previous experiments also suggest this. This work is significant because it is the first time anyone has shown that such chemical modifications could change the behavior of a protein in this way, and also that it could have important consequences for the way proteins interact. If you have questions, please ask away. We will assign badges and update the webpage soon.


Bitcoin Donations
Source:  yoyo@home
jeudi 23 octobre 2014 00:00

You can send donations now also via Bitcoin to our Bitcoin address. Infos on our donation page.


Competition 'SAT@home. Three years with the project.'
Source:  SAT@home
jeudi 23 octobre 2014 08:06

Competition SAT@home. Three years with the project. will be held from October 3 2014 to October 10 2014.

Соревнование SAT@home. Три года с проектом. будет проведено с 3 по 10 октября 2014 года.


12-digit factor of P2203 has now been found by the project...
Source:  WEP-M+2 Project
dimanche 19 octobre 2014 12:53

...56186 times


Planned outage
Source:  NFS@Home
vendredi 17 octobre 2014 01:13

The NFS@Home project will be offline for part of this weekend due to a planned data center outage. Everything should be back online Sunday.


GPUGRID statistics graphs
Source:  GPUGrid
jeudi 16 octobre 2014 03:17

Following up on the announcement to discontinue support for old hardware and the oldest application, here are two graphs showing the normalised throughput of GPUGRID broken down by compute capability and application version. http://www.gpugrid.net/graphs/ The legends are messed up for some reason - the first graph is cc, {1.3, 2.0, 2.1, 3.0, 3.5, 5.0, 5.2 }, the second app version {42, 60, 65} These will update daily. Matt


GARLI 2.1 released
Source:  The Lattice Project
mercredi 15 octobre 2014 19:48

I have just released GARLI 2.1 for five platforms (32 and 64 bit Linux, 32 and 64 bit Windows, 64 bit OS X), and have deprecated the 32 bit OS X app version. This version should improve data set load times for large analyses, and may include other improvements that you would notice. Please post if you encounter any problems running the new version.


Server Reboot and Maintenance
Source:  Milkyway@home
mercredi 15 octobre 2014 14:55

Hey everyone,

We will be doing a quick server reboot and some updating today. If you notice any issues please post them here.

Jake W.


Version 2.02 of pdsat_crypto released
Source:  SAT@home
mardi 14 octobre 2014 08:12

Выпущено приложение pdsat_crypto версии 2.02. Ускорен процесс решения на задачах криптоанализа Bivium примерно на 15 %.

Version 2.02 of the application pdsat_crypto released. Performance on Bivium problem was increased by about 15%.


New CPU work units
Source:  GPUGrid
dimanche 12 octobre 2014 13:53

I'm starting testing again on the "cpumd" multi-threaded CPU app. Please post observations here. Matt



   

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