Actualités en direct des projets (non traduites)

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Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

• SARS-CoV-2 main protease (3CLpro) further studies
  
  This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.
  
  
• Ebolavirus glycoprotein (GP)
  
  Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.
  
  
• Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)
  
  This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

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Création : 26 janvier 2024

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There were a lot of notification issues since 14th while the project email account was blocked. A small change today fixed it including UOTD.

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Création : 23 janvier 2024

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Part 2 of the 10^21 search will be over some time in March this year, so it's time to start getting ready for part 3! I found a few bugs in the current GPU applications that needed to be fixed (CPU applications are fine).

To make sure everything works as intended, I will launch a small beta-test of the part 3 search by the end of this week. The new work units will require ~2.5-2.7 GB RAM on CPU, and the same amount of RAM on GPU (for GPU applications), so the minimum requirement for GPUs will be 3 GB RAM.

The purpose of the test is to confirm that all OS/CPU/GPU combinations work properly and confirm that 3 GB GPUs can process the new work units.

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Création : 22 janvier 2024

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Just a heads up, the server was upgraded to the latest version of Ubuntu this morning.

The database seems to be crashing every so often with an error about exceeding max connections. Bear with me as we look into this.

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Création : 19 janvier 2024

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Aliquot sequence 2990736 has terminated!!!



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Création : 17 janvier 2024

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We continue our work on characterizing lung cancer biomarkers identified in the MCM1 project. This update focuses on PCSK5, a gene associated with lung cancer survival and which shows differential expression across various cancer types.

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Création : 16 janvier 2024