Actualités en direct des projets (non traduites)

Détails

Dear participants,

After doing initial studies on an established SARS-CoV-2 target RNA dependent RNA polymerase (RdRp), we are departing from protease studies and focus on RdRp along with additional NSP targets. Namely, RdRp (NSP12), is responsible for the transcription of viral genes and ultimately replication of the viral genome. The studied active site binds RNA and was previously studied in the context of remdesivir, galidesivir, molnupiravir and several other small molecules. Further reading below:

• Structure of replicating SARS-CoV-2 polymerase
  
• Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity
  
• RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2
  
• Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
  

Figure 1: RdRp in white color along with RNA chain and N4-hydroxycytidine from Molnupiravir in the active site (red stick model).

With best wishes,
Natalia, Marko, ÄŒrtomir, hoarfrost.

Source

Création : 15 janvier 2023

Détails

Dear participants!

We created new applications named as "CurieMarieDock 0.2.0 long tasks" and "CurieMarieDock 0.2.0 short tasks", both based on CmDock 0.2.0 release. Algorithm of both applications are identical, but for "short tasks" we created only ARM-version and we plan to generate a special, smaller in 5 times tasks that covers one of part of entire tasks set. We advice all owners of small single-board computers like Raspberry Pi, to switch to "short tasks" application.

In next 1 .. 2 days we continue to generate new tasks "Sprot_delta_v1" (extended run) for both application, but later we issue a sample tasks set for new target (# 22) and only for "long application" because all task of sample set will be large. Simultaneously, project will continue to send Sprot_delta_v1 tasks for "short" application. And then we will proceed to sent long and short tasks for appropriate applications.

Hope that this explanation makes situation is clear.

Thank you for participation and donation of CPU time!

Source

Création : 13 janvier 2023

Détails

As I said. We are currently compiling the Windows version. GDF

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Création : 10 janvier 2023

Détails

Simone Bonzanini found a 67 digits prime factor for the Cuningham number 22222+1. This saves a lot of NFS effort. The found prime is the first for this years ECMNET record list of Paul Zimmermann.

Source

Création : 8 janvier 2023

Détails

The OpenIFS model batches require the option 'Leave non-GPU in memory while suspended' to be enabled under boincmgr -> Disk&Memory. This will prevent the task from frequently restarting and reduce the risk of task failure.

Source

Création : 5 janvier 2023

Détails

2022 was the year of ℚ(√-10) (subfield 7), as most of our time was spent on that search. Many new fields were found and we are now entering the final row of the search. In the next 3 to 6 months we should be at the point where we can say with almost certainty that it is complete.

The goals for 2023 are simple:
1. Get subfield 7 to the point where it is essentially complete.
2. Go back and officially complete subfield 3, so we can say with 100% certainty that it is done.
3. Do more on subfield 7 or move on to subfield 6 (the final search).

Thanks everyone for your contributions and have a wonderful New Year!

Source

Création : 1 janvier 2023